Statistical Modeling of Lung Cancer: Answering Relative Questions

نویسندگان

  • Chunling Cong
  • James Kepner
  • Chris. P. Tsokos
چکیده

THE OBJECTIVE OF THIS PAPER IS TO PERFORM PARAMETRIC AND NONPARAMETRIC ANALYSIS TO ADDRESS SOME VERY IMPORTANT QUESTIONS CONCERNING LUNG CANCER UTILIZING REAL LUNG CANCER DATA: What is the probabilistic nature of mortality time in ex-smoker lung cancer patients and non-smoker lung cancer patients, for female, male, and the totality of female and male patients? Is there significant difference of mortality time between ex-smoker and non-smoker patients? For ex-smokers, are there any differences with respect to the key variables such as mortality time, cigarettes per day (CPD), and duration of smoking between female and male patients? For non-smokers, can we notice a difference in mortality time between female and male patients? Can we accurately predict mortality time given information on CPD, starting time and quitting time for a specific lung cancer patient who smokes? Thus best fitting probability distributions are identified and their parameters are estimated. Mean mortality times are compared between non-smokers and ex-smokers, female non-smokers and male non-smokers, and female ex-smokers and male ex-smokers. Important entities related to lung cancer mortality time, such as cigarettes per day (CPD), and duration of smoking (DUR), are compared between female and male ex-smoker lung cancer patients. Finally, a model is developed to predict the mortality time of ex-smokers with a high degree of accuracy.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Modeling Community Question-Answering Archives

Community Question Answering (CQA) services contain large archives of previously asked questions and their answers. We present a statistical topic model for modeling Question-Answering archives. The model explicitly captures relationships between questions and their answers by modeling topical dependencies. We show that the model achieves improved performance in retrieving the correct answer fo...

متن کامل

Living (and Dying) in a Deterministic World

Biostatistical models typically describe associations answering questions like • Are people who smoke more likely to be diagnosed with lung cancer? or • Do HIV-infected patients treated with drug A live longer (or in the shorter term have lower viral load measurements) than similar patients treated with drug B? using cohort studies and clinical trials, respectively, to collect the data necessar...

متن کامل

Quantile Probability and Statistical Data Modeling

Quantile and conditional quantile statistical thinking, as I have innovated it in my research since 1976, is outlined in this comprehensive survey and introductory course in quantile data analysis. We propose that a (grand) unification of the theory and practice of statistical methods of data modeling may be possible by a quantile perspective. Our broad range of topics of univariate and bivaria...

متن کامل

Cluster-Based Query Expansion for Statistical Question Answering

Document retrieval is a critical component of question answering (QA), yet little work has been done towards statistical modeling of queries and towards automatic generation of high quality query content for QA. This paper introduces a new, cluster-based query expansion method that learns queries known to be successful when applied to similar questions. We show that cluster-based expansion impr...

متن کامل

Assessment of lung cancer risk due to indoor radon exposure in inhabitants of the state of Azad Kashmir Pakistan

Background: Several epidemiological studies conducted on underground miner’s show that exposure to elevated levels of radioactive radon gas is expected to increase the risk of lung cancer. Relative risk of lung cancer is almost linear with radon exposure. Elevated concentrations of radon are not only reported within mines but also for closed indoor environment of general public houses....

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2011